Scientific Activities (up to 2007)

ORGANIZATION OF SCIENTIFIC MEETINGS

1996.9
Organizer, TMIN Symposium/The Second International Symposium on Protein Phosphatases "Protein Phosphatases & Cellular Regulation" (Tokyo, Japan)

1997.10
Organizer, TMIN International Symposium 1997 "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (Tokyo, Japan)

1998.11
Co-organizer, The Third International Symposium on Protein Phosphatases "Cellular Regulation by Protein Phosphatases" (Hiroshima, Japan)

2000.11
Co-organizer, The Fourth International Conference on Protein Phosphatases "Roles of Protein Phosphatases in Intracellular Signaling Systems" (Sendai, Japan)

2002.3
Co-organizer, The Fifth International Conference on "Protein Phosphatases and Cellular Regulation" (Okazaki, Japan)

2003.7
Co-organizer, The First Japanese Conference on “Protein Phosphatases” (Sapporo, Japan)

2004.2
Co-organizer, The 6th International Conference on “Protein Phosphatases & International Symposium on Nano-Biotechnology” (Okayama, Japan)

PUBLICATION

Papers

Ozawa T, Nakata K, Mizuno K & Yakura H (2007) Negative autoregulation of Src homology region 2-domain-containing phosphatase 1 in rat basophilic leukemia-2H3 cells. Int Immunol 19: 1049-1061

Mizuno K, Tagawa Y, Watanabe N, Ogimoto M & Yakura H (2005) SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation. Eur J Immunol 35: 644-654

Ogimoto M, Ichinowatari G, Watanabe N, Tada N, Mizuno K & Yakura H (2004) Impairment of B cell receptor-mediated Ca2+ influx, activation of mitogen-activated protein kinases and growth inhibition in CD72-deficient BAL-17 cells. Int Immunol 16: 971-982

Shrivastava P, Katagiri T, Ogimoto M, Mizuno K & Yakura H (2004) Dynamic regulation of Src-family kinases by CD45 in B cells. Blood 103: 1425-1432

Mizuno K, Tagawa Y, Mitomo K, Watanabe N, Katagiri T, Ogimoto M & Yakura H (2002) Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. J Immunol 169: 778-786

Adachi T, Wienand J, Wakabayashi C, Yakura H, Reth M & Tsubata T (2001) SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem 276: 26648-26655

Arimura Y, Ogimoto M, Mitomo K, Katagiri T, Yamamoto K, Volarevic S, Mizuno K & Yakura H (2001) CD45 is required for CD40-induced inhibition of DNA synthesis and regulation of c-Jun NH2-terminal kinase and p38 in BAL-17 B cells. J Biol Chem 276: 8550-8556

Ogimoto M, Arimura Y, Katagiri T, Mitomo K, Woodgett JR, Nebreda AR, Mizuno K & Yakura H (2001) Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45. FEBS Lett 490: 97-101

Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR & Kikutani H (2000) Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling. Immunity 13: 621-631

Mizuno K, Tagawa Y, Mitomo K, Arimura Y, Hatano N, Katagiri T, Ogimoto M & Yakura H (2000) Src homology 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells. J Immunol 165: 1344-1351

Uetani N, Kato K, Ogura H, Mizuno K, Kawano K, Mikoshiba K, Yakura H, Asano M & Iwakura Y (2000) Impaired learning with enhanced hippocampal long-term potentiation in PTPδ-deficient mice. EMBO J 19: 2775-2785

Adachi T, Wakabayashi C, Yakura H & Tsubata T (1999) CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol 164: 1223-1229

Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K, Okada M, Clark MR, Mizuno K & Yakura H (1999) CD45 negatively regulates Lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells. J Immunol 163: 1321-1326

Hasegawa K, Yajima H, Katagiri T, Ogimoto M, Arimura Y, Mitomo K, Mashima K, Mizuno K & Yakura H (1999) Requirement of PEST domain tyrosine phosphatase PEP in B cell antigen receptor-induced growth arrest and apoptosis. Eur J Immunol 29: 887-896

Adachi T, Flaswinkel H, Yakura H, Reth M & Tsubata T (1998) The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol 160: 4662-4665

Mizuno K, Katagiri T, Maruyama E, Hasegawa K, Ogimoto M & Yakura H (1997) SHP-1 is involved in neuronal differentiation of P19 embryonic carcinoma cells. FEBS Lett 417: 6-12

Nomura T, Han H, Howard MC, Yagita H., Yakura H, Honjo T & Tsubata T (1996) Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. Int Immunol 8: 867-875

Mizuno K, Katagiri T, Hasegawa K, Ogimoto M & Yakura H (1996) Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med 184: 457-463

Katagiri T, Ogimoto M, Hasegawa K, Mizuno K & Yakura H (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-27990

Ogimoto M, Katagiri T, Mashima K, Hasegawa K, Mizuno K & Yakura H (1995) Antigen receptor-initiated growth inhibition is blocked in CD45-loss variants of a mature B lymphoma, with limited effects on apoptosis. Eur J Immunol 25: 2265-2271

Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T & Yakura H (1995) Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3. Cytogenet Cell Genet 70: 52-54

Mizuno K, Hasegawa K, Ogimoto M, Katagiri T & Yakura H (1994) Developmental regulation of gene expression for the MPTPδ isoforms in the central nervous system and the immune system. FEBS Lett 355: 223-228

Ogimoto M, Katagiri T, Mashima K, Hasegawa K, Mizuno K & Yakura H (1994) Negative regulation of apoptotic death in immature B cells by CD45. Int Immunol 6: 647-654

Ogimoto M, Katagiri T, Hasegawa K, Mizuno K & Yakura H (1993) Induction of CD45 isoform switch in murine B cells by antigen receptor stimulation and by phorbol myristate acetate and ionomycin. Cell Immunol 151: 97-109

Mizuno K, Hasegawa K, Katagiri T, Ogimoto M, Ichikawa T & Yakura H (1993) MPTPδ, a putative murine homolog of HPTPδ, is expressed in specialized regions of the brain and in the B-cell lineage. Mol Cell Biol 13: 5513-5523

Hasegawa K, Ariyama T, Inazawa J, Mizuno K, Ogimoto M, Katagiri T & Yakura H (1993) Chromosomal assignment of the gene for protein tyrosine phosphatase HPTPδ. Jpn J Cancer Res 84: 1219-1222

Ogimoto M, Mizuno K, Tate G, Takahashi H, Katagiri M, Hasegawa K & Yakura H (1992) Regulation of lipopolysaccharide- and IL-4-induced immunoglobulin heavy chain gene activation: differential roles for CD45 and Lyb-2. Int Immunol 4: 651-659

Ashida T, Kubo K, Kawabata I, Katagiri M, Ogimoto M & Yakura H (1990) Signal transduction mechanisms of Ia induction in B cells by interleukin 4 and immunoglobulin receptors. Cell Immunol 126: 233-238

Kobata T, Yagita H, Matsuda H, Tansyo S, Yakura H, Katagiri M & Okumura K (1990) A novel homodimeric molecule involved in human T cell activation. J Immunol 144: 830-835

Daita G, Yonemasu Y, Ishikawa M, Shimizu T & Yakura H (1989) Intracranial malignant teratoma diagnosed in a fetus. Neurol Med Chir 29: 1026-1029

Yakura H, Ashida T, Kawabata I & Katagiri M (1989) Alleviation of autoimmunity in BXSB mice by monoclonal alloantibody to Ly-5 (CD45). Eur J Immunol 19: 1505-1508

Ashida T, Yakura H, Kawabata I, Murakami M & Katagiri M (1988) Structural features of the Lyb-2 molecule. Immunogenet 28: 286-288

Yakura H, Kawabata I, Ashida T, Shen FW & Katagiri M (1986) A role for Lyb-2 in B cell activation mediated by a B cell stimulatory factor. J Immunol 137: 1475-1481

Yakura H, Kawabata I, Shen FW & Katagiri M (1986) Selective inhibition of lipopolysaccharide-induced IgG response by monoclonal Ly-5 antibody. J Immunol 136: 2729-2733

Yakura H, Shen FW, Bourcet E & Boyse EA (1983) On the function of Ly-5 in the regulation of antigen-driven B cell differentiation. Comparison and contrast with Lyb-2. J Exp Med 157: 1077-1088

Yakura H, Shen FW, Bourcet E & Boyse EA (1982) Evidence that Lyb-2 is critical to specific activation of B cells before they become responsive to T cell and other signals. J Exp Med 155: 1309-1316

Yakura H, Shen FW, Kaemmer M & Boyse EA (1981) Lyb-2 system of mouse B cell. Evidence for a role in the generation of antibody-forming cells. J Exp Med 153: 129-135

Yakura H, Shen FW, Boyse EA & Tang L (1980) The Lyb-2 phenotype of hemolytic PFC. Immunogenet 10: 603-605

Sasazuki T, McMichael A, Payne R, McDevitt HO, Yakura H, Wakisaka A, Aizawa M & Itakura K (1977) An HLA-D specificity found in the Japanese population. Tissue Antigens 9: 62-65

Yakura H, Wakisaka A, Aizawa M, Itakura K, Tagawa Y & Sugiura S (1976) HLA-D antigen of Japanese origin (LD-Wa) and its association with Vogt-Koyanagi-Harada syndrome. Tissue Antigens 8: 35-42

Wagatsuma Y, Yakura H, Nakayama E, Wakisaka A, Aizawa M, Miyata M, Matsuyama R, Sato M & Itakura K (1976) Inheritance of asthma in families and its linkage to HLA haplotypes. Acta Allergol 31: 455-462

Tagawa Y, Sugiura S, Yakura H, Wakisaka A, Aizawa M & Itakura K (1976) HLA and Vogt-Koyanagi-Harada syndrome. N Eng J Med 295: 173

Yakura H, Wakisaka A, Fujimoto S & Itakura K (1974) Hereditary ataxia and HL-A genotypes. N Eng J Med 291: 154-155

Nakayama E, Itakura K, Yakura H, Aizawa M, Kuroda M & Hanada K (1974) Sa 1, a possible new HL-A specificity found in the Japanese population. Vox Sang 27: 134-140

Reviews

Yakura H (1998) Phosphatases and kinases in lymphocyte signaling. Immunol Today 19: 198-2016

Yakura H (1994) The role of protein tyrosine phosphatases in lymphocyte activation and differentiation. Crit Rev Immunol 14: 311-336

Shen FW, Yakura H & Tung JS (1982) Some compartments of B cell differentiation. Immunol Rev 69: 69-80

Itakura K, Yakura H, Nakayama E & Aizawa M (1975) HL-A and MLC antigens in the Japanese population. Keio J Med 24: 377-391

Books

Yakura H (editor) (1997) Kinases and Phosphatases in Lymphocyte and Neuronal Signaling. Springer-Verlag, Tokyo, Japan

Yakura H, Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K & Mizuno K (1997) Protein tyrosine phosphatases in B lymphocyte signaling. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan. pp.134-146

Mizuno K, Katagiri T, Hasegawa K, Arimura Y, Mitomo K, Ogimoto M & Yakura H (1997) Possible involvement of Src homology region 2 domain-containing phosphatase-1, SHP-1, in neuronal differentiation. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan. pp. 310-311

Uetani N, Asano M, Mizuno K, Yakura H & Iwakura Y (1997) Targeted disruption of the murine protein tyrosine phosphatase delta (MPTPδ) gene results in growth retardation and behavioral abnormalities. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan. pp. 313-314

Hasegawa K, Katagiri T, Ogimoto M, Arimura Y, Mizuno K, Mitomo K & Yakura H. Role of PEST domain tyrosine phosphatase PEP in B cell antigen receptor-induced signaling. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan 1997. pp. 325-326

Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K, Mizuno K & Yakura H. CD45 differentially regulates B cell antigen receptor-mediated tyrosine phosphorylation in immature and mature B cell. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan 1997. pp. 328-329

Ogimoto M, Arimura Y, Mitomo K, Katagiri T, Hasegawa K, Mizuno K & Yakura H. Regulation of MAP kinases and NF-κB activation by CD45 in WEHI-231 and BAL-17 B cells. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan 1997. pp. 330-331

Arimura Y, Ogimoto M, Mitomo K, Katagiri T, Hasegawa K, Mizuno K & Yakura H. Role of CD45 in CD40 signaling in mature B lymphoma cells. In "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (ed, Yakura H) Springer-Verlag, Tokyo, Japan 1997. pp. 334-335

Yakura H, Tate G, Sakata H, Kawabata I, Ashida T & Katagiri M (1988) Regulation of lipopolysaccharide-induced B cell differentiation by Ly-5 and Lyb-2 molecules. In “Lymphocyte
Activation and Differentiation” (eds, Mani JC, & Dornand J) Walter de Gruyter & Co, Berlin, Germany. pp. 595-598

Murakami M, Miyokawa N, Yakura H, Ikeda H & Katagiri M (1986) A non-DR and –DQ class II molecule detected by monoclonal antibody AS-9C4. In ”HLA in Asia-Oceania 1986” (ed, Aizawa M) Hokkaido Univ Press, Sapporo, Japan. pp. 439-447

Aizawa M, Yakura H, Wakisaka A, Maruyama N, Kimura S, Moriuchi J, Kuroda M, Hamatake K & Itakura K (1975) Analysis of the Workshop sera against Japanese permanent panel. In “Histocompatibility Testing 1975” (ed, Kissmeyer-Nielsen F) Munksgaard, Copenhagen, Denmark. pp. 136-142

<Articles & Books in Japanese not listed>

SYMPOSIA

2006.5.15
SHP-1 dephsohprylates SHP-1 and SLP-76, thereby inactivating SHP-1 in mast cells. Block Symposium "Mast Cells and Basophils", Immunology 2006. (Bonston, MA, USA)

2005.10.21
Regulation of mast cell activation by protein tyrosine phosphatase SHP-1. Symposium on "Novel signaling pathways involved in allergic reactions", The 55th Japanese Society of Allergology. (Morioka, Japan)

2005.7.11
PTPε negatively regulates FcεRI-mediated mast cell activation. Europhosphatases Conference 2005. "The Biology of Phosphatases" (Cambridge, UK)

2005.4.3
Inhibitory regulation of FcεRI-mediated mast cell functions by SHP-1. Block Symposium "Mast cells", Experimental Biology 2005. The 92st AAI Meeting. (San Diego, CA, USA)

2004.12.2
Regulation of mast cell activation by protein tyrosine phosphatases. Symposium on “Role of protein phosphatases in the immune signaling”, The 34th Japanese Society of Immunology (Sapporo, Japan)

2004.2.18
Regulation of lymphocyte and mast cell signaling by protein tyrosine phosphatases. The Sixth International Conference on “Protein Phosphatases and International Symposium on Nano-Biothechnology” (Okayama, Japan)

2002.10.17
Present state and future direction in protein phosphatase research. Symposium on "New Developments in Protein Phosphatase Research", The 72nd Japanese Biochemical Society (Yokohama, Japan)

2002.5.14
Regulation of mast cell activation by protein tyrosine phosphatases. Osaka University Medical School Symposium “Biology of Mast Cells and Basophils” (Osaka, Japan)

2002.3.14
Novel, dynamic regulation of Src-family tyrosine kinases by CD45. The Fifth International Conference on “Protein Phosphatases and Cellular Regulation” (Okazaki, Japan)

2000.11.12
Dynamic regulation of lymphocyte signaling by protein tyrosine phosphatase CD45. The fourth International Conference on "Roles of Protein Phosphatases in Intracellular Signaling Systems" (Sendai, Japan)

2000.6.4
Role of protein tyrosine phosphatases in lymphocyte signaling and brain functions. International Symposium on “Neuronal Signaling and Protein Phosphorylation-Dephosphorylation” (Fukuoka, Japan)

1999.12.2
Inhibitory co-receptors on B lymphocytes. Symposium "Inhibitory receptors and signals in the immune regulation", The 29th Japanese Society for Immunology (Kyoto, Japan)

1999.10.7
Regulation of Src-family tyrosine kinases by CD45. Symposium on "Regulation of Signal Transduction by Protein Phosphatases", The 72nd Japanese Biochemical Society (Yokohama, Japan)

1999.10.7
Role of PTPδ in neuronal function. Symposium on "Regulation of Signal Transduction by Protein Phosphatases", The 72nd Japanese Biochemical Society (Yokohama, Japan)

1999.5.15
Regulation of Src-family tyrosine kinases by CD45 in B cells. Cold Spring Harbor Meeting on "Tyrosine Phosphorylation & Cell Signalling" (Cold Spring Harbor, NY, USA)

1999.4.20
Differential regulation of MAPKs by CD45 in two different B cell lines. Block Symposium "B Lymphocyte Activation", Experimental Biology '99 (Washington, DC, USA)

1999.4.18
Requirement of PEST domain tyrosine phosphatase PEP in BCR-induced growth arrest and apoptosis. Block Symposium "B Lymphocyte Apoptosis", Experimental Biology '99 (Washington, DC, USA)

1998.11.21
Targeted disruption of the MPTPδ gene results in growth retardation and abnormal behavior. The 3rd International Symposium on "Cellular Regulation by Protein Phosphatases" (Hiroshima, Japan)

1998.11.21
The role of protein tyrosine phosphatases in B lymphocyte signaling. The 3rd International Symposium on "Cellular Regulation by Protein Phosphatases" (Hiroshima, Japan)

1998.10.17
Regulation of mast cell activation by protein tyrosine phosphatases. Symposium on "The New Development in Protein Phosphatases", The 71st Japanese Biochemical Society (Nagoya, Japan)

1997.10.16
Possible involvement of Src homology region 2 domain-containing phosphatase-1, SHP-1, in neuronal differentiation. The 13th TMIN International Symposium on "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (Tokyo, Japan)

1997.10.15
Regulation of B cell signaling by protein tyrosine phosphatases. The 13th TMIN International Symposium on "Kinases and Phosphatases in Lymphocyte and Neuronal Signaling" (Tokyo, Japan)

1997.9.24
Regulation of neuronal cell differentiation by PTP. Minisymposium on "Protein Phosphatases in Signal Transduction Pathways", The 70th Japanese Biochemical Society (Kanazawa, Japan)

1996.11.26
Tyrosine phosphatases in B cell antigen receptor-mediated signaling. Symposium on "Molecular Mechanisms of Antigen Receptor Signals", The 26th Japanese Society for Immunology (Yokohama, Japan)

1996.9.27
Negative regulation of Lyn tyrosine kinase by CD45 in immature B cells. TMIN Symposium on "Protein Phosphatases and Cellular Regulation" (Tokyo, Japan)

1996.9.26
Possible involvement of protein tyrosine phosphatases in neuronal differentiation of P19 embryonic carcinoma cells. TMIN Symposium on "Protein Phosphatases and Cellular Regulation" (Tokyo, Japan)

1994.9.7
Search for substrates of CD45 in immature B cells. Colloquium on "Growth and Death of Lymphocytes", The 67th Japanese Biochemical Society (Osaka, Japan)

1994.5.28
Tyrosine phosphatases involved in the regulation of the immune system. Symposium on "Regulation of Cellular Functions and Protein Phosphatases", The 60th Japanese Biochemical Society in Tohoku (Akita, Japan)

1994.4.28
Role for CD45 in B cell activation and inactivation. Minisymposium on "Molecular Aspects of B Cell Development and Differentiation", Experimental Biology '94 (Anaheim, CA)

1987.11
Regulation of B cell growth and differentiation by Lyb-2 and Ly-5. “Lecture A of Japanese Society of Pathology” (Tokyo, Japan)

1986.1
Analysis of B cell differentiation by anti-receptor antibodies. “Symposium of Ministry of Health and Welfare of Japan” (Tokyo, Japan)

1985.5
Two molecules involved in B cell activation: Lyb-2 and Ly-5. “First Symposium of Japanese Society for Immunology” (Fukuoka, Japan)

1985.4
Lyb-2 as a possible B cell growth factor (BCGF) I receptor. Minisymposium “B cell activation”, American Association of Immunologists

SEMINARS

2006.2.16
National University of Singapore, Singapore
“Regulation of lymphocyte and mast cell activation by protein tyrosine phosphatases”

2005.7.4
Hôpital Necker-Enfants Malades - Paris V, Paris, France
“Régulation de l’activation des lymphocytes et des mastocytes par protéine-tyrosine phosphatases”

2005.6.28
l’Institut de Signalisation et Innovation Thérapeutique - Université Paris-Sud XI., Châtenay-Malabry, France
“Régulation de l’activation des lymphocytes et des mastocytes par protéine-tyrosine phosphatases”

2005.6.23
Institut Pasteur, Paris, France
“Regulation of lymphocyte and mast cell signaling by tyrosine phosphatases”

2002.4.10
Tokyo University of Agriculture and Technology, Tokyo, Japan
“Regulation of two biological systems by protein tyrosine phosphatases”

2001.7.20
Institut Pasteur, Paris, France
“Role of protein tyrosine phosphatases in lymphocyte signaling”

2001.7.13
University of Rijeka, Rijeka, Croatia
“Regulation of lymphocyte signaling by protein tyrosine phosphatases”

2001.5.22
McGill Cancer Centre, McGill University, Montreal, Canada
“Regulation of lymphocyte signaling by CD45”

2000.1.27
Asahikawa Medical College, Asahikawa, Japan
“Lymphocyte signaling and tyrosine phosphatases”

1999.6.1
Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
“Protein tyrosine phosphatases in lymphocyte signal transduction”

1999.5.10
University of Texas MD Anderson Cancer Center, Houston, USA
“Protein tyrosine phosphatases in B cell fate determination”

1999.4.14
Pennsylvania State University College of Medicine, Hershey, USA
“Protein tyrosine phosphatases regulating B cell receptor signaling”

1999.4.12
Indiana University School of Medicine, Indianapolis, USA
“Protein tyrosine phosphatases that determine lymphocyte fate”

1999.3.8
Institute of Immunological Science, Hokkaido University, Sapporo, Japan
“Regulatory mechanisms of tyrosine phosphatases in lymphocyte signal transduction”

1998.10.30
Institute of Molecular and Cell Biology, National University of Singapore, Singapore
“The role of protein tyrosine phosphatases in lymphocyte signaling”

1998.10.23
National Institute for Basic Biology, Okazaki, Japan
“Regulation of the immune system by protein tyrosine phosphatases”

1998.3.12
Research Laboratory, Otsuka America Pharmaceutical, Inc., Bethesda, USA
“Protein tyrosine phosphatases in lymphocyte signaling”

1998.1.30
Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
“Regulation of lymphocyte signal transduction by tyrosine phosphatases”

1998.1.27
Okayama University School of Medicine, Okayama, Japan
“Lymphocyte signal transduction and protein tyrosine phosphatases”

1997.7.24
Institute of Immunology, University of Heidelberg, Heidelberg, Germany
“Protein tyrosine phosphatases and B cell signal transduction”

1997.7.18
Max-Planck Institute for Immunobiology, Freiburg, Germany
“Protein tyrosine phosphatases in B lymphocyte signaling”

1997.7.16
Basel institute for Immunology, Basel, Switzerland
“Protein tyrosine phosphatases in BCR signal transduction”

1997.7.15
Friedrich Miescher Institute, Basel, Switzerland
“Regulation of lymphocyte signaling by protein tyrosine phosphatases”

1997.7.2
Otsuka Pharmaceutical Co., Tokushima, Japan
“Signal transduction of B lymphocytes and protein tyrosine phosphatases”

1997.6.26
Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan
“Mechanisms of B cell activation”

1997.5.14
Babraham Institute, Cambridge, UK
“Regulation of B cell signaling by protein tyrosine phosphatases”

1995.8.4
University of Iowa College of Medicine, Iowa City, USA
“Regulation of B cell signal transduction by protein tyrosine phosphatases”

1994.10 .12
Institute of Immunological Science, Hokkaido University, Sapporo, Japan
“Regulation of the immune system by protein tyrosine phosphatases”

1994.1.14
Institute of Medical Science, University of Tokyo, Tokyo, Japan
“Regulation of lymphocyte activation by protein tyrosine phosphatases”

1992.7.31
Asahikawa Medical College, Asahikawa, Japan
“Regulation of immune and nervous systems by receptor-type protein tyrosine phosphatases”

1992.7.27
National Jewish Center for Immunology and Respiratory Medicine, Denver, USA
“Receptor-type protein tyrosine phosphatases expressed in the immune and central nervous systems”

1991.5.3
University of Texas MD Anderson Cancer Center, Houston, USA
“Regulatory mechanisms of B lymphocyte differentiation by CD45, a protein tyrosine phosphatase, and Lyb-2”

1991.4.29
University of Miami School of Medicine, Miami, USA
“Regulation of B cell differentiation by Lyb-2 and a transmembrane tyrosine phosphatase CD45 ”

1989.10 .23
Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
“B cell activation and immunological abnormalities”

1989.8.8
Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
“Regulation of antibody class by differentiation antigens and its clinical relevance”

1989.5.17
Allergy Consortium, Chiba University, Chiba, Japan
“Regulation of antibody class switch and treatment of autoimmune disorders”

1989.2.15
Institute of Immunological Science, Hokkaido University, Sapporo, Japan
“Regulatory mechanisms of B cell differentiation and potential therapeutic strategies for autoimmune diseases”

1984.8.29
Clinical Research Centre, Harrow, UK
“Differentiation antigens that regulate B cell differentiation”

1983.1.11
State University of New York, Stony Brook, USA
“Mechanisms of B lymphocyte activation”

1982.9.10
Institute of Immunology, Chiba University, Chiba, Japan
“Mechanisms of lymphocyte differentiation mediated by B cell differentiation antigens”

1982.5.26
Downstate Medical Center, State University of New York, Brooklyn, USA
“Regulation of B cell differentiation by non-immunoglobulin allotypic molecules”

1978.1.3
Harvard Medical School, Boston, USA
“Role of T lymphocytes in the immune response to Listeria monocytogenes”